Titlebook: Behavioral Neuroscience of Orexin/Hypocretin; Andrew J Lawrence,Luis de Lecea Book 2017 Springer International Publishing AG 2017 orexin/h

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Orexin/Hypocretin Signaling,X. orexin receptors, as described in the previous chapters. Signaling of orexin peptides has been investigated in diverse endogenously orexin receptor-expressing cells – mainly neurons but also other types of cells – and in recombinant cells expressing the receptors in a heterologous manner. Finding

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Orexin/Hypocretin and Organizing Principles for a Diversity of Wake-Promoting Neurons in the Brain,ustness via redundancy’, wherein wakefulness control is not critically dependent on one type of neuron or molecule. Studies of the brain orexin/hypocretin system challenge this view by demonstrating that wakefulness control fails upon loss of this neurotransmitter system. Since orexin neurons signal

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The Hypocretin/Orexin Neuronal Networks in Zebrafish,eding, sleep wake cycle, reward-seeking, addiction, and stress. Loss of Hcrt neurons causes the sleep disorder narcolepsy. The zebrafish has become an attractive model to study the Hcrt neuronal network because it is a transparent vertebrate that enables simple genetic manipulation, imaging of the s

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Hypocretins and Arousal, to narcolepsy has undoubtedly allowed us to advance our knowledge on key mechanisms controlling the boundaries and transitions between sleep and wakefulness. Lack of function of hypocretin neurons (a relatively simple and non-redundant neuronal system) results in inappropriate control of sleep stat

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Orexin OX2 Receptor Antagonists as Sleep Aids,and their two receptors play a major role in arousal and sleep/wake cycles. Defects in the orexin system lead to narcolepsy with cataplexy in humans and dogs and can be experimentally reproduced in rodents. At least six orexin receptor antagonists have reached Phase II or Phase III clinical trials i

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Roles for Orexin/Hypocretin in the Control of Energy Balance and Metabolism,roject widely throughout the brain and the physiologic and behavioral functions of OX are much more complex than initially conceived based upon the stimulation of feeding. OX most notably controls functions relevant to attention, alertness, and motivation. OX also plays multiple crucial roles in the

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