Titlebook: Attempts to Understand Metastasis Formation I; Metastasis-Related M Ursula Günthert,Walter Birchmeier Book 1996 The Editor(s) (if applicabl

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Model Systems of Carcinoma Cell Dispersion,n the mouse skin system, for example, the loss of epithelial differentiation is accompanied by the appearance of malignant properties. In this well-studied system, chemical carcinogenesis generates multiple benign tumors, a proportion of which develop to form squamous cell carcinomas and, in extreme

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,Involvement of α6 and αv Integrins in Metastasis,y cels of the primary tumor is involved in this event, for example, E-cadherin in carcinomas (Frixen et al. 1991) and α4 integrin in melanomas (Qian et al. 1994). Migrating metastatic cells enter the blood vasculature or the lymphatics through which they are transported to peripherical organs. In th

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CD44 in Maligant Disorders,n embryogenesis, and inflammatory reactions. Possible explanations for the supposedly multipurpose nature of CD44 include the existence of an enormous number of isoforms and/or the potential likelihood that the role of CD44 in all these diverse processes is not as manifold as it sounds, because we s

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B2SAT: A Bare-Metal Reduction of?B to?SATned within a defined space, most neoplasms could be removed and subsequently cured with the surgeon’s scalpel. However, this is not the case within the scope of cancer biology. Some neoplasms are highly metastatic (melanoma), while others are rarely metastatic (brain tumors), but given enough time a

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Stochastic Games for?User Journeyson itself does not mean immediate use of the enzymes for tumor invasion or for the remodeling of the extracellular matrix (ECM), processes associated with tumor growth. MMPs are produced and secreted as zymogens (pro-MMPs) that need proteolytic activation for the enzymes to function (. 1991; . et al

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Xiang He,Bohan Li,Mengyu Zhao,Shaowei Caidevelopment, would healing and tumor growth. Angiogenesis requires a strict temporal modulation of opposing cell functions: cell proliferation and migration, and extracellular matrix (ECM) degradation in the initial steps; arrest of cell proliferation and migration, ECM deposition and morphogenesis

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Xiang He,Bohan Li,Mengyu Zhao,Shaowei Cai of its expression at the mRNA level in normal but not in tumor-derived mammary epithelial cells (. et al. 1994). The cloned and sequenced cDNA consists of 2584 nucleotides encoding a 42 kDa peptide with the overall structure of a serpin. Maspin has been localized to chromosome 18q21.3-q23 (. et al.