| 期刊全稱 | Attempts to Understand Metastasis Formation I | | 期刊簡(jiǎn)稱 | Metastasis-Related M | | 影響因子2023 | Ursula Günthert,Walter Birchmeier | | 視頻video | http://file.papertrans.cn/165/164879/164879.mp4 | | 學(xué)科分類 | Current Topics in Microbiology and Immunology | | 圖書(shū)封面 |  | | 影響因子 | In metastasis, tumor cells disseminate from the primary lesion and home to secondary organs where they may remain dormant for a long time. Metastasis formation is still the most feared manifestation for tumor patients and clinicians. Although improvements have been made concerning earlier detection and specific therapy, most of the cancer patients still die of distant metastases. The pu-rpose of these three volumes is to review the recent progress in molecular metas- tasis research and to attempt to further understand the biol- ogy of this multifocal process. With respect to present day molecular biology, the pioneers of metastasis research established the basic concepts of metasta- sis formation in the 1970s and 1980s, namely, clonal selection of metastatic cells, heterogeneity of metastatic subpopulations, organ specificity of metastasis and the importance of angio- genesis (Fidler, Kripke, Nicolson, Folkman and others). In the 1980s and 1990s, several of the molecules involved were identified and their network interactions elucidated. These three volumes of Current Topics in Microbiology and Immuno- logy compile the most recent developments on these meta- stasis-related molecule | | Pindex | Book 1996 |
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