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Titlebook: Angiotensin II Receptor Blockade Physiological and Clinical Implications; Naranjan S. Dhalla (Distinguished Professor and Di Book 1998 Spr

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發(fā)表于 2025-3-21 16:05:37 | 只看該作者 |倒序瀏覽 |閱讀模式
期刊全稱Angiotensin II Receptor Blockade Physiological and Clinical Implications
影響因子2023Naranjan S. Dhalla (Distinguished Professor and Di
視頻videohttp://file.papertrans.cn/158/157433/157433.mp4
學科分類Progress in Experimental Cardiology
圖書封面Titlebook: Angiotensin II Receptor Blockade Physiological and Clinical Implications;  Naranjan S. Dhalla (Distinguished Professor and Di Book 1998 Spr
影響因子The relationship between angiotensin II and hypertension was established in 1898 when angiotensin II was shown to modulate systemic blood pressure. Over the intervening decades, a complete characterization of the renin-angiotensin system (RAS) has been achieved, and our understanding of its biochemistry and physiology has led to the directed development of agents such ·as ACE inhibitors and receptor antagonists capable of controlling hypertension. More recently, it was shown that angiotensin II is secreted within certain tissues and that these tissue-specific systems operate independently of the systemic RAS. The novel concept that angiotensin II regulates a number of cardiovascular processes that are unrelated to blood pressure has renewed the interest of both basic and clinical scientists in angiotensin II. The association between angiotensin II and cardiac growth, in particular, has indicated that therapies currently in use for hypertension may have direct application to the treatment of heart failure. The Manitoba Cardiovascular Forum on Angiotensin Receptor Blockade in Winnipeg was convened October 18-20, 1996 to examine the clinical and basic aspects of angiotensin receptor b
Pindex Book 1998
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Cellular Physiology of Angiotensin II Receptors in Vascular Smooth Muscle Cellsnctions have been defined. The developmental regulation of AT. receptor expression, however, suggests that it may be important in ontogeny. Furthermore, the generation of an AT. receptor knockout mouse has revealed that this receptor, although its absence is not lethal, governs both the drinking res
地板
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Angiotensin II Enhanced The Expression Of Inhibitory Guanine Nucleotide Regulatory Protein in Vasculrotein as well as the attenuated responsiveness of adenylyl cyclase to Ang II and C-ANP. inhibition. The results suggest the implication of AT. receptor in Ang II-induced increases of Giα protein expression in vascular smooth muscle cells.
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Comparison of the Inhibitory Actions of Angiotensin AT1 Receptor Antagonists in the Peripheral Vascurictor responses to the angiotensin peptides in the regional vascular bed of the cat. In the rat, candesartan decreased pressor responses to Ang II, whereas PD 123,319 had no effect on the response to the peptide. These results indicate that vasoconstrictor responses to Ang peptides in the regional
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Exploring the Difference Between Angiotensin Converting Enzyme Inhibitors and Angiotensin II-Recepto that would compare agents with a bradykinin effect, namely, ACE inhibitors, with those without a bradykinin effect. Thus far, the trials have shown great similarity between the agents in the field of hypertension and those of cardiac failure.
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In Pursuit of Optimal Care and Outcomes for Patients with Congestive Heart Failure: Insights from thprogression of heart failure, although noncardiac causes, particularly cancer and pulmonary diseases, account for about 30 percent of all deaths. Therapy proven to reduce overall mortality in CHF is presently limited to angiotensin-converting enzyme inhibitors (ACEI) , although angiotensin receptor
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