Titlebook: Aging Mechanisms II; Longevity, Metabolis Nozomu Mori Book 2022 The Editor(s) (if applicable) and The Author(s), under exclusive license to

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,Conrad Ferdinand Meyers religi?se Welt,ated program characterized by the irreversible arrest of the cell cycle in damaged, proliferating cells. Senescence is a potent tumor-suppressor cell state; by the same token, however, it is also a primary driver of the aging process and age-related diseases. Outside of this conventional view, sever

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https://doi.org/10.1057/9781137400437h as energy metabolism, DNA repair, epigenetic regulation, and neuronal axon homeostasis. Several studies have shown that tissue NAD. levels decrease with aging. This age-related NAD. decline has been associated with hallmarks of aging and the development and progression of a wide range of age-relat

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Ukrainian Soviet Socialist Republic,igh prevalence and significant impact on adverse health outcomes. Several international working groups have reported diagnostic criteria for sarcopenia, and it is now common to diagnose sarcopenia based on skeletal muscle mass, muscle strength, and physical performance. As countermeasures, resistanc