Titlebook: Aging Mechanisms; Longevity, Metabolis Nozomu Mori,Inhee Mook-Jung Book 2015 Springer Japan 2015 Aging.Brain.Longevity.Metabolism.Neurodege

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α-Klotho in Health and Diseasesssues that are involved in mineral homeostasis, and it encodes a 130-kDa type I glycoprotein. α-Kl was first predicted to localize to the cell surface. However, large amounts of α-Kl proteins have been detected in the intra-cellular space. In addition, the extra-cellular domain is cleaved, and secre

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AMBI

Cellular Longevity of Budding Yeast During Replicative and Chronological Aging., rapamycin). We reviewed methodological properties of CLS and RLS, and discussed genes related to these lifespans. Particularly, we focused on two genes, Sir2 and Tor1, in context of their association with replicative and chronological cellular aging. We also described novel genes and primary biol

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Genes and Pathways That Influence Longevity in ,ression of genes involved in each pathway and system alter longevity. We also speculate on the evolutionary significance of the genes and pathways that affect longevity. Given the conserved nature of longevity regulation, the dissection of the roles of these genetic factors in determining the . life

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α-Klotho in Health and Diseasesex to plasma membrane. On the membrane, α-Kl forms a ternary complex with FGF23 and FGFR1 and negatively regulates 1, 25(OH).D synthesis and phosphate re-absorption in the kidney. As a down-steam event of hypervitaminosis D and hyperphosphatemia, Calpain-1 is greatly activated and is responsible for