Titlebook: Hypoxia and Cancer Metastasis; Daniele M. Gilkes Book 2019 Springer Nature Switzerland AG 2019 hypoxia.cancer.HIF.metastasis.angiogenesis

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Hypoxia and the Metastatic Niche,vely remodeled by secretory factors including growth factors, chemokines and cytokines, extracellular matrix (ECM) enzymes, and exosomes produced by the primary cancer tissues. Many of the associated-secretory factors are abundantly induced by inflammation and hypoxia. These secretory factors modify

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Hypoxia-Induced Resistance to Chemotherapy in Cancer, property of malignant cells developed prior to therapy, or acquired following exposure to anti-cancer drugs. Given the impact of drug resistance to the overall poor survival of cancer patients, there is an urgent need to better understand the molecular pathways regulating this malignant phenotype.

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