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Titlebook: Hypoxia and Cancer Metastasis; Daniele M. Gilkes Book 2019 Springer Nature Switzerland AG 2019 hypoxia.cancer.HIF.metastasis.angiogenesis

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發(fā)表于 2025-3-21 18:30:20 | 只看該作者 |倒序瀏覽 |閱讀模式
書目名稱Hypoxia and Cancer Metastasis
編輯Daniele M. Gilkes
視頻videohttp://file.papertrans.cn/431/430811/430811.mp4
概述Focuses on understanding the negative impact of hypoxia in cancer progression.Describes how hypoxia promotes key events that lead to cancer metastasis.Provides current approaches used clinically and p
叢書名稱Advances in Experimental Medicine and Biology
圖書封面Titlebook: Hypoxia and Cancer Metastasis;  Daniele M. Gilkes Book 2019 Springer Nature Switzerland AG 2019 hypoxia.cancer.HIF.metastasis.angiogenesis
描述.The present book is an attempt to provide a detailed review of studies that clarify our current understanding of the role of hypoxia in the progression of primary cancer to metastatic disease. It will enable researchers to discover the critical cellular changes that occur under hypoxic conditions and play a role in metastatic dissemination, from the activation of hypoxia-inducible factors, HIF-1 and HIF-2, to the transcriptional profile changes that occur in cancer cells and promote cancer cell survival under detrimental conditions..Readers will discover the methods and challenges involved in imaging and quantifying the degree of hypoxia in a primary tumor. We will provide an understanding of the hypoxia-induced phenotypes that influence heterogeneity, alter the secretome and tumor microenvironment, modify cellular metabolism, and promote immune suppression and resistance to chemotherapy. Finally, we will uncover the therapeutic strategies that are being devised to target the hypoxic microenvironment in the hopes of preventing metastasis and improving the efficacy of standard-of-care cancer treatments. ..This work is an up to date source of information on the challenges and comple
出版日期Book 2019
關(guān)鍵詞hypoxia; cancer; HIF; metastasis; angiogenesis
版次1
doihttps://doi.org/10.1007/978-3-030-12734-3
isbn_softcover978-3-030-12736-7
isbn_ebook978-3-030-12734-3Series ISSN 0065-2598 Series E-ISSN 2214-8019
issn_series 0065-2598
copyrightSpringer Nature Switzerland AG 2019
The information of publication is updating

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發(fā)表于 2025-3-21 21:17:58 | 只看該作者
Clinical and Pre-clinical Methods for Quantifying Tumor Hypoxia,complexity and heterogeneity across tumor types and individuals. Most standard imaging techniques can be modified and applied to measuring hypoxia and quantifying its effects; however, the benefits and challenges of each imaging modality makes imaging hypoxia case-dependent. In this chapter, a compr
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Hypoxia and the Metastatic Niche,ass immune surveillance and propagate. Endothelial cell-to-cell junctions of blood vessels are loosened to enhance the penetrance of metastatic cancer cells to the metastatic sites. Different metastatic tissues have unique ECM constituents, resident immune cells, and anatomical positions linked with
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Mechanistic Justifications of Systemic Therapeutic Oxygenation of Tumors to Weaken the Hypoxia Induent cancer immunotherapies without simultaneous administration of anti-Hypoxia-A2A-Adenosinergic drugs that inactivate this tumor-protecting mechanism in hypoxic and adenosine-rich tumors..Here, we overview the supporting evidence for the conceptually novel immunotherapeutic motivation to breathe su
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Wie aus der Zahl ein Zebra wirdcomplexity and heterogeneity across tumor types and individuals. Most standard imaging techniques can be modified and applied to measuring hypoxia and quantifying its effects; however, the benefits and challenges of each imaging modality makes imaging hypoxia case-dependent. In this chapter, a compr
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Rechnungslegung nach dem neuen Aktiengesetz,ass immune surveillance and propagate. Endothelial cell-to-cell junctions of blood vessels are loosened to enhance the penetrance of metastatic cancer cells to the metastatic sites. Different metastatic tissues have unique ECM constituents, resident immune cells, and anatomical positions linked with
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0065-2598 metastasis.Provides current approaches used clinically and p.The present book is an attempt to provide a detailed review of studies that clarify our current understanding of the role of hypoxia in the progression of primary cancer to metastatic disease. It will enable researchers to discover the cri
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