Titlebook: Voltage-gated Ca2+ Channels: Pharmacology, Modulation and their Role in Human Disease; J?rg Striessnig Book 2023 The Editor(s) (if applica

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0171-2004 Moreover, the long-sought molecular basis for key regulatory pathways have been discovered as well as exciting concepts of their subtype-selective pharmacological modulation..978-3-031-38439-4978-3-031-38437-0Series ISSN 0171-2004 Series E-ISSN 1865-0325

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Ca,3.2 (,) in Primary Aldosteronismfied in familial hyperaldosteronism, whereas somatic mutations are a rare cause of aldosterone-producing adenomas. In this review, we summarize these findings, put them in perspective, and highlight missing knowledge.

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Book 2023ffecting the pore-forming as well as accessory subunits and channel-interacting proteins. Moreover, the long-sought molecular basis for key regulatory pathways have been discovered as well as exciting concepts of their subtype-selective pharmacological modulation..

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CaV1.1 Calcium Channel Signaling Complexes in Excitation–Contraction Coupling: Insights from Channelchannel (Ca.1.1), located in the sarcolemma and functioning as the voltage sensor of EC coupling, and the ryanodine receptor 1 (RyR1), located on the sarcoplasmic reticulum serving as the calcium release channel. To this day, the molecular mechanism by which these two ion channels are linked remains

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Sympathetic Nervous System Regulation of Cardiac Calcium Channels rate of cardiac contraction are modulated by the sympathetic nervous system, mediated substantially by changes in intracellular calcium. Norepinephrine released from sympathetic neurons innervating the heart and epinephrine secreted by the adrenal chromaffin cells bind to β-adrenergic receptors on

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Modulation of CaV1.2 Channel Function by Interacting Proteins and Post-Translational Modifications: pertension, atherosclerosis, myocardial infarction, and heart failure. But, a few controversies still remain. Therefore, exploring new ways to modulate Ca.1.2 channel activity will augment the arsenal of Ca.1.2 channel-based therapeutics for treatment of cardiovascular diseases. Here, we will mainly

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Design and Applications of Genetically-Encoded Voltage-Dependent Calcium Channel Inhibitorsnd physiological functions including neurotransmission, muscle contraction, and regulation of gene expression. The impressive ability of a singular signal, Ca. influx, to have such a plethora of functional outcomes is enabled by: molecular diversity of HVGCC pore-forming α. and auxiliary subunits; o