Titlebook: Voltage Gated Sodium Channels; Peter C. Ruben Book 2014 Springer-Verlag Berlin Heidelberg 2014 channelopathies.drug binding.selectivity.st

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Slow Inactivation of Na+ Channels,ures myocytes are able to contract when K. is elevated. The molecular mechanisms underlying slow inactivation are unclear even though it has been studied for 50+ years. This chapter reviews what is known to date regarding the definition, measurement, and mechanisms of voltage-gated Na. channel slow inactivation.

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Slow Inactivation of Na+ Channels, reducing availability of inward current. In neurons, slow inactivation has been linked to memory of previous excitation and in skeletal muscle it ensures myocytes are able to contract when K. is elevated. The molecular mechanisms underlying slow inactivation are unclear even though it has been stud

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,The Role of Non-pore-Forming β Subunits in Physiology and Pathophysiology of Voltage-Gated Sodium Cfamily members, β1B, β3, and β4, were identified by homology and shown to modulate sodium current in heterologous systems. Work over the past 2 decades, however, has provided strong evidence that these proteins are not simply ancillary ion channel subunits, but are multifunctional signaling proteins