Titlebook: Vitamin D; Physiology, Molecula Michael F. Holick Book 2010Latest edition The Editor(s) (if applicable) and The Author(s), under exclusive

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The Molecular Biology of the Vitamin D Receptorhe VDR binds 1,25(OH).D with high affinity and high selectivity. In the target cell, the interaction of the 1,25(OH).D hormone with VDR initiates a complex cascade of molecular events culminating in alterations in the rate of transcription of specific genes or gene networks. This chapter discusses t

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Mechanism of Action of 1,25-Dihydroxyvitamin D3 on Intestinal Calcium Absorption and Renal Calcium Tn, the basolateral plasma membrane pump, and the epithelial calcium channel, TRPV6. Calcium can enter the enterocyte through the epithelial calcium channel and then bind to calbindin and move through the cytosol. At the basolateral membrane calcium is transported actively by the plasma membrane calc

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Biological and Molecular Effects of Vitamin D on Bonedevelopment and turnover of bone, differentiation and survival of distinct bone cell populations, and maintaining calcium and bone homeostasis through positive and negative control of gene expression. Here we describe these functional activities within the context of the molecular mechanisms establi

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Diversity of Vitamin D Target Geneslular growth, differentiation, and in controlling inflammation. Many of these VDR target genes are also involved in dysregulated pathways leading to common human diseases, such as cancer, osteoporosis, or the metabolic syndrome. The activation of VDR by natural and synthetic ligands may improve such

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