| 書目名稱 | Virtual Screening: An Alternative or Complement to High Throughput Screening? | | 副標題 | Proceedings of the W | | 編輯 | Gerhard Klebe | | 視頻video | http://file.papertrans.cn/984/983375/983375.mp4 | | 圖書封面 |  | | 描述 | In the next couple of years the human genome will be fullysequenced. This will provide us with the sequence and overall functionof all human genes as well as the complete genome for manymicro-organisms. Subsequently it is hoped, by means of powerfulbioinformatic tools, to determine the gene variants that contribute tovarious multifactorial diseases and genes that exist in certaininfectious agents but not humans. As a consequence, this will allow usto define the most appropriate levels for drug intervention. It can beexpected that the number of potential drug targets will increase,possibly by a factor of 10 or more. Nevertheless, sequencing the humangenome or, for that matter, the genome of other species will only bethe starting point for the understanding of their biological function.Structural genomics is a likely follow-up, combined with newtechniques to validate the therapeutic relevance of such newlydiscovered targets. Accordingly, it can be expected that in the nearfuture we will witness a substantial increase in novel putativetargets for drugs. To address these new targets effectively, werequire new approaches and innovative tools. At present, twoalternative, yet complementar | | 出版日期 | Conference proceedings 2002 | | 關鍵詞 | chemistry; drug; drugs; future; research | | 版次 | 1 | | doi | https://doi.org/10.1007/0-306-46883-2 | | isbn_softcover | 978-90-481-5584-2 | | isbn_ebook | 978-0-306-46883-4 | | copyright | Springer Science+Business Media Dordrecht 2002 |
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