Titlebook: Viral Vectors in Veterinary Vaccine Development; A Textbook Thiru Vanniasinkam,Suresh K. Tikoo,Siba K. Samal Textbook 2021 Springer Nature

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What Is Required to Develop a Viral Vector Vaccine: Key Components of Vaccine-Induced Immune Responsls. These considerations may be of particular importance when considering different target populations for vaccination, such as either very young or elderly individuals. Finally, screening vaccine vector candidates for efficacy is dependent upon the availability of an appropriate disease model. This

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Poxvirus Vectors cell culture. Most of the recombinant poxviruses developed to date have targeted insertional inactivation of the thymidine kinase (TK) gene, in which the heterologous gene is inserted in the TK locus?in the poxvirus genome. In recent years, other immunomodulatory genes have also been used to genera

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Paramyxoviruses as Vaccine Vectors This chapter describes our current knowledge of paramyxovirus biology, genome replication, reverse genetics, construction of vaccine vectors, advantages and limitations of paramyxovirus vectors, and specific recombinant paramyxoviruses used for veterinary vaccine development.

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Manufacturing and Control of Viral Vectored Vaccines: Challengesuse of continuous cell lines in suspension and in medium without substances of animal origin or chemically defined, using single-use technology, automatization, digitalization, data management and artificial intelligence.

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Regulatory Strategies and Factors Affecting Veterinary Viral Vector Developmentnges in tropism. A risk assessment of potential impact on human health and environment is built based on data obtained with the vaccine candidate and scientific literature on the vector and inserted sequences. Critical efficacy factors include the minimum protective dose and the potential interferen

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rform a “complete” analysis of all the known regulatory effectors in the cell. This lack of certainty comes about not only because of the ever-present possibility that compounds which were not measured are important regulatory substances, but also because frequently the enzymes and/or putative regul

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Teshome Mebatsionion (15). We have recently shown that TFX is a potent inducer of helper T cells for antibody production in man. However, when TFX is added to lymphocytes generating high numbers of plasma cells in culture the resulting immunoglobulin synthesis is markedly reduced (7, 8). This data indicates that in