| 書目名稱 | Vesicle Trafficking in Cancer | | 編輯 | Yosef Yarden,Gabi Tarcic | | 視頻video | http://file.papertrans.cn/983/982686/982686.mp4 | | 概述 | Discusses the evolutionary basis of endocytic pathways.Examines the lipid composition of the endosomal pathway.Explore mathematical modeling of endocytosis | | 圖書封面 |  | | 描述 | Endocytosis and vesicular trafficking determine the landscape of the cell’s exterior, namely the density of surface molecules, such as receptors for growth factors and cytokines, adhesion molecules like integrins and cadherins, and a plethora of nutrient carriers. Hence, endocytosis is involved in signal transduction, cell adhesion and migration, as well as metabolism. To exploit these fundamental processes, malignancies subtly and multiply manipulate the endocytosis and the subsequent trafficking of protein cargoes. This is achieved by simultaneously altering the cytoskeleton, vesicle budding, cargo sorting and intracellular degradation. By highlighting the underlying molecular processes and concentrating on specific examples, this book reviews the recent emergence of derailed endocytosis and vesicular trafficking as a landmark of cancer. In-depth understanding of this common feature of tumors might lead the way to drug-induced strategies, able to rectify intracellular trafficking in cancer. | | 出版日期 | Book 2013 | | 關(guān)鍵詞 | C-Met signaling; endocytosis; endosomal pathway; oxidative stress; Receptors | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-4614-6528-7 | | isbn_softcover | 978-1-4899-9496-7 | | isbn_ebook | 978-1-4614-6528-7 | | copyright | Springer Science+Business Media New York 2013 |
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