Titlebook: Venom Genomics and Proteomics; P. Gopalakrishnakone,Juan J. Calvete Living reference work 20200th edition

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2542-761X nology, including topics like bioterrorism, toxin evolution In recent years, the field of Toxinology has expanded substantially. On the one hand it studies venomous animals, plants and micro organisms in detail to understand their mode of action on targets. While on the other, it explores the bioche

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Automated Mass Fingerprinting of Venoms in Nanogram Range: Review of Technology,ingerprinting (VMF) which depicts the venom’s all-inclusive masses may be very informative when comparisons among close or distant venomous species have to be pictured, as well as intraspecific venom variations. This chapter reports, as an example, the technological requirements and pitfalls using t

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Biological Activities and Assays of the Snake Venom Metalloproteinases (SVMPs), three main groups based on the presence or absence of domains: PI – which contains only a metalloproteinase domain; PII – includes also a disintegrin domain; and PIII – in addition to the first two domains, possesses a cysteine-rich domain. Diverse functions have been described to this group of pro

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Industrial Production and Quality Control of Snake Antivenoms, purification, viral inactivation (or removal), and stabilization of the formulation. In order to manufacture products of satisfactory effectiveness and safety, antivenom design must be validated by preclinical and clinical studies. Moreover, during the industrial production, the quality of the prod

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Purinergic Mechanisms of Prey Acquisition by Venomous Organisms,t help in the acquisition of prey and its digestion. The venom also serves as a defensive armament in protecting itself against the predators and aggressors. The diverse and synergistically acting cocktail of biologically active molecules of the venoms have been evolved with precise function to inte

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Scorpion Venom Gland Transcriptomics and Proteomics: An Overview,sity of animal venoms from various species including scorpions. During the last decade, proteomics analysis of 27 different scorpion species has been conducted and revealed the complexity of scorpion venoms. Mass fingerprinting data clearly showed noticeable differences in the number of venom molecu