Titlebook: Vascular Disease and Injury; Preclinical Research Daniel I. Simon,Campbell Rogers Book 2001 Springer Science+Business Media New York 2001 S

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Folts Cyclic Flow Animal Model for Studying in Vivo Platelet Activity and Platelet Interactions withd decreases in coronary flow so that controlled increments of ischemia would be induced. Such a model would require the production of a fixed amount of stenosis, which would allow for essentially normal coronary flow with the animal at rest, but would cause ischemia and sudden death under many of th

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Mouse Models of Atherosclerosiso hypercholesterolemia and atherogenesis, identification of genes determining the susceptibility of mice to atherosclerosis and advances in gene knockout and transgene techniques have led to the generation of murine models that develop extensive atherosclerosis. These models offer new insights into

Madrigal

Rabbit Models of Atherosclerosisical studies have demonstrated that lowered cholesterol plays a role in reducing acute coronary events .. In the early 20th century, Anitschkow found that a cholesterol-enriched diet could induce atherosclerosis in rabbit arteries, and established a relationship between cholesterol consumption and s

Latency

Atherosclerosis in Nonhuman Primatesten respond to lipidemic stimulus with the production of lipoproteins resembling those seen in man. The disadvantages are that nonhuman primates are expensive to purchase and maintain, and they are often difficult to handle. Nevertheless, there has been considerable activity in this area of research

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Murine Carotid Loop Model of Transplant Vascular Diseaseimal formation in vessels of transplanted organs—remains a major obstacle to long-term graft survival .. This disease does not respond to current immunosuppressive therapy and its underlying pathogenesis is not fully understood. Indeed, animal models represent an invaluable determinant in biological

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Book 2001s related to vascular disease and injury in five major areas: acute mechanical injury and vascular repair, arterial thrombosis, chronic atherosclerosis,vascular disease in transplanted vessels, and vascular disease in systemic and pulmonary arterial hypertension. Up-to-date and highly practical, Vas

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Atherosclerotic Porcine Coronary Stent Models of spontaneous atherosclerosis have limited availability, and their cost is prohibitive for most experimental applications. Porcine coronary models have been developed that use dietary manipulation and arterial injury to produce an accelerated atherosclerotic lesion ..

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