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Titlebook: Valproate; Wolfgang L?scher Book 1999 Springer Basel AG 1999 bipolar disorder.chemistry.clinical trial.development.drug.drugs.epilepsy.med

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發(fā)表于 2025-3-21 19:56:34 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
書目名稱Valproate
編輯Wolfgang L?scher
視頻videohttp://file.papertrans.cn/981/980289/980289.mp4
叢書名稱Milestones in Drug Therapy
圖書封面Titlebook: Valproate;  Wolfgang L?scher Book 1999 Springer Basel AG 1999 bipolar disorder.chemistry.clinical trial.development.drug.drugs.epilepsy.med
描述Since the fortuitous discovery of its anticonvulsant activIty in 1962, valproate has established itself worldwide as a major antiepileptic drug against several types of epileptic seizures. Clinical experience with valpro- ate has continued to grow in recent years, including use of valproate for diseases other than epilepsy, for example in bipolar disorders and migraine. In this volume on valproate emphasis is placed on the scientific back- ground leading to the discovery of val pro ate, its subsequent pharmacologi- cal and toxicological characterization, and its clinical development into one of the most widely and successfully used anti epileptic drugs, a real mile- stone in drug therapy. The current state of knowledge of valproate will be reviewed by experts in the field, including new hypotheses about its mecha- nisms of action, its metabolism into pharmacologically active metabolites, its unique distribution characteristics, its unwanted hepatotoxic and terato- genic adverse effects and its various clinical uses. Furthermore, the wide variety of available pharmaceutical formulations of valproate, including novel controlled-release formulations, will be outlined. The monograph is
出版日期Book 1999
關(guān)鍵詞bipolar disorder; chemistry; clinical trial; development; drug; drugs; epilepsy; medicinal chemistry; metabo
版次1
doihttps://doi.org/10.1007/978-3-0348-8759-5
isbn_softcover978-3-0348-9761-7
isbn_ebook978-3-0348-8759-5Series ISSN 2296-6056 Series E-ISSN 2296-6064
issn_series 2296-6056
copyrightSpringer Basel AG 1999
The information of publication is updating

書目名稱Valproate影響因子(影響力)




書目名稱Valproate影響因子(影響力)學(xué)科排名




書目名稱Valproate網(wǎng)絡(luò)公開度




書目名稱Valproate網(wǎng)絡(luò)公開度學(xué)科排名




書目名稱Valproate被引頻次




書目名稱Valproate被引頻次學(xué)科排名




書目名稱Valproate年度引用




書目名稱Valproate年度引用學(xué)科排名




書目名稱Valproate讀者反饋




書目名稱Valproate讀者反饋學(xué)科排名




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Pharmacological effects and mechanisms of actionin recent years, including use of valproate for diseases other than epilepsy, e.g. in bipolar disorders and migraine. In the following, the preclinical pharmacological profile of valproate and the putative mechanisms involved will be reviewed.
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Chemistry and biotransformationsign of new efficacious antiepileptic drugs having minimal sideeffects and free of the undesired interactions with other antiepileptic agents, structure-activity relationship studies of VPA analogues and metabolites have played a pivotal role towards the development of new antiepileptic agents [4–7]
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Book 1999 its unique distribution characteristics, its unwanted hepatotoxic and terato- genic adverse effects and its various clinical uses. Furthermore, the wide variety of available pharmaceutical formulations of valproate, including novel controlled-release formulations, will be outlined. The monograph is
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Frank S. Abbott,M. Reza Anari(SNR) of atomic shot noise and laser frequency noise. The estimated SNR of the designed cesium beam tube is over 7000 in a 1?Hz detection bandwidth. The influence of the deflection angle of the collimator on the performance of the beam tube is analyzed. The method can be used to guide the design of
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