Titlebook: Validation of Alternative Methods for Toxicity Testing; Chantra Eskes,Maurice Whelan Book 2016 The Editor(s) (if applicable) and The Autho

COMA

廚師

Validation of Alternative In Vitro Methods to Animal Testing: Concepts, Challenges, Processes and Td suites, data sources and decision-aiding tools. Data generated with alternative approaches are ultimately used for decision-making on public health and the protection of the environment. It is therefore essential that the underlying methods and methodologies are thoroughly characterised, assessed

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MITE

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Evidence-Based Toxicology,rivers spurring the development of EBT..In the context of pathway-based toxicology, EBT approaches, given their objectivity, transparency and consistency, have been proposed to be used for carrying out a (retrospective) mechanistic validation..In summary, implementation of more evidence-based approa

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Validation of Transcriptomics-Based , Methods,his chapter describes those aspects that were identified as important in the validation process of transcriptomics-based tests, including the assessment of standardisation, reliability and relevance. It also critically discusses the challenges posed to validation in relation to the specific characte

FECK

Ensuring the Quality of Stem Cell-Derived , Models for Toxicity Testing,iative. Accordingly, the chapter summarizes the most up-date best practices in the use and quality control of human Pluripotent Stem Cell lines in the development of . toxicity assays from leading experts in the field.

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