Titlebook: Vaccines; Peter Perlmann (Professor),Hans Wigzell (Professor Book 1999 Springer-Verlag Berlin Heidelberg 1999 Allergie.Antigen.Autoaggress

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DNA Vaccines: Immunogenicity and Preclinical Efficacy,exploring basic questions related to antigen processing and presentation. DNA vaccines differ from traditional vaccines in that, rather than consisting of the antigen itself (in the form of an inactivated or attenuated pathogen) or of a purified or recombinant component of the pathogen (eg., bacteri

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Antigen-Presentation Systems, Immunomodulators, and Immune Responses to Vaccines,d in healthy subjets by exposure to live micro-organisms with a reduced virulence profile obtained either by use of the corresponding pathogen of another animal species (e.g., smallpox, rotavirus vaccines) or by in vitro attenuation [e.g., poliomyelitis, measles, mumps, rubella or bacille Calmette-G

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Vaccines Against Measles, Mumps, Rubella, and Varicella,ystemic childhood disease, and infection with wild-types of each of these viruses bequeaths a life-long protection upon renewed exposure to the infectious agent. Furthermore, live vaccines effectively preventing each of these tour diseases have been developed by empirical techniques. However, there

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Herpes,ish R(. and S. 1996), indicating a long coevolution of this virus family and animal life. A typical herpesvirus consists of a core containing a linear, double-stranded DNA of 150–230 kb, an icosahedral capsid of 162 capsomeres (100–110 nm in diameter), a surrounding amorphous material (the tegument)

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Toxin-Based Vaccines (Diphtheria, Tetanus, Pertussis),festations of diphtheria and tetanus can be thoroughly reproduced by the systemic administration of the toxins. Both diseases can be prevented by administration of toxin-neutralizing antibodies or by immunization with partially purified and detoxified toxins (toxoids). Diphtheria and tetanus vaccine

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Carbohydrate-Based Bacterial Vaccines, of the polysaccharides to a carrier protein improves immunogenicity (A. and G. 1969). The development of methods to purify high molecular weight meningococcal capsular polysaccharides led the administration of vaccines to humans (G. et al. 1969).

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Mycobacteria,he current vaccine against tuberculosis, bacille Calmette-Guérin (BCG), has a highly variable record of protection, and a widely accepted need exists for improved vaccines to control this disease. Infection with tuberculosis triggers a broad spectrum of immune responses which can contribute to elimi

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Vaccines Against Diarrheal Diseases,lion deaths, occur annually in developing countries with the highest incidence and severity in children below the age of 5 years (F. and K. 1989; WHO 1996). The vast majority of these diseases are caused by enteric infections. The etiological agents include a large number of bacteria, some viral age

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Sexually Transmitted Diseases,TDs tend to be asymptomatic as a sign of adaptation to the human host. This is also reflected in their species specificity, i.e., humans, which in the context of vaccines hampers our ability to study them in animal models. They are common worldwide and pose significant health problems, principally d