Titlebook: Vaccine Protocols; Andrew Robinson,Graham H. Farrar,Christopher N. Wi Book 19961st edition Humana Press 1996

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書目名稱Vaccine Protocols影響因子(影響力)




書目名稱Vaccine Protocols影響因子(影響力)學(xué)科排名




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書目名稱Vaccine Protocols被引頻次




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書目名稱Vaccine Protocols讀者反饋




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Temperature-Sensitive Mutant Vaccines,ly successful in controlling poliomyelitis are the prime example of this phenomenon. The three live attenuated strains developed by Sabin were derived from wild-type isolates by rapid sequential passage at high multiplicity of infection in monkey tissue in vitro and in vivo, a regimen that yielded v

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Development of Attenuated , Strains that Express Heterologous Antigens,s a system for delivering foreign antigens to the mammalian immune system. DNA capable of driving the expression of heterologous antigens can be introduced into . vaccine strains using a variety of approaches. In general, there are two common methods of expressing a foreign antigen in salmonellae: f

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Chimeric Proteins, several limitations. Large-scale growth of pathogens may be difficult to achieve and is not completely free of risk. Furthermore, purification of relevant antigenic components from such pathogens may be expensive and time-consuming. Another approach is the use of synthetic peptides corresponding to

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The Use of Adjuvants in Experimental Vaccines,preparation because of its extensive use in experimental vaccines in animals, its strong adjuvant effect, and the considerable literature describing its activity. The combination of mineral oil (Bayol 55) and dead mycobacterial organisms produces a specific cellular reaction in experimental animals.

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The Use of Adjuvants in Experimental Vaccines,iety of natural phospholipids or other polar amphiphiles can be used in an aqueous solution of an antigen to form either unilamellar or multilamellar spherules. The antigen(s) may either be lipid-soluble and insert into the artificial lipid bilayer, bmd to the bilayer, or become entrapped inside the