Titlebook: Vaccine Design; The Role of Cytokine Gregory Gregoriadis,Brenda McCormack,Anthony C. Al Book 1997 Springer Science+Business Media New York

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Development of Parainfluenza Virus and Respiratory Syncytial Virus Subunit Vaccines,arainfluenza viruses, PIV-3 is second only to RSV as the causative agent of bronchiolitis and pneumonia in infants less than 6 months of age. Annually, approximately 1,000 infants may die in the United States from severe respiratory tract infections caused by PIV-3. Furthermore, it is estimated that

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A Single Treatment with Adjuvant Stimulates Th1-Like Cytokines and Downregulates Th2-Mediated Primat al, 1993a; Seder et al., 1993; Brinkmann et al., 1993; Wenner et al., 1996). Differentiated, antigen-specific Thl cells produce IFN-γ, IL-2 and TNF-6 (Abbas et al., 1996). Th1 cells promote DTH and complement-fixing, IgG2a antibody production in mice, while the Th2 subset promotes the formation of