Titlebook: Vaccine Design; The Role of Cytokine Gregory Gregoriadis,Brenda McCormack,Anthony C. Al Book 1997 Springer Science+Business Media New York

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,Development of an Influenza-Iscom? Vaccine,rently available vaccines ranges from 60 to 80% in young healthy adults, but is usually lower in the elderly (Fedson et al, 1993; Govaert et al. 1994). Vaccine uptake is less than optimal (CDC 1995; Nguyen-Van-Tarn and Nicholson, 1993) especially in this target group. Various ways have been investig

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Mucosal Vaccines: Perspectives on the Development of Anti-H.pylori Vaccines,c cancer (Parsonnet et al., 1991; Parsonnet et al., 1994; Blaser and Parsonnet, 1994). The risk of infection is high in childhood and is directly correlated to hygienic conditions and overcrowded homes (Webb et al., 1994). Once established, a successful colonization may be lifelong. Due to significa

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A Single Treatment with Adjuvant Stimulates Th1-Like Cytokines and Downregulates Th2-Mediated Prima nature of the subsequent immune response, designing vaccines which favor the appropriate T cell subset is of critical importance. Two subsets of mature Th cells, Th1 and Th2, have been distinguished based upon the pattern of cytokines they produce (Mosmann and Coffman, 1989; Brown et al., 1989). An

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The Potential Use of Different Vaccination Protocols to Tailor Cytokine Profiles,es have shown the existence of two types of Th cells that could be distinguished on the basis of their cytokine production (Mosmann et al., 1986; Mosmann and Coffman, 1989). The Th1 subset secretes IL-2 and IFN-γ, and preferentially promotes cell-mediated immunity and IgG2a production by B lymphocyt

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Modulation of Cytokine Responses by Iscoms and Iscom-Matrix, activity in the same particle (Morein et al, 1984). In electron microscopy, the iscoms appear as organized cage-like structures of 30–40 nm in diameter (?zel et al, 1989). Chemically, iscoms consist of glycosylated triterpenoids from . Molina, cholesterol, phospholipids and amphipathic protein anti

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Vaccines and Vaccine Delivery Systems: Experience with HSV, Influenza and Mucosal Routes of Immunisces. It follows that, depending on the numbers of virions deposited on such surfaces, their infectious quality and distribution over the mucosal surface, the existence or early mobilisation of specific defence mechanisms at the time of this contact, supplementing or enhancing any non-specific resist