Titlebook: Vaccine Design; The Subunit and Adju Michael F. Powell,Mark J. Newman Book 1995 Plenum Press, New York 1995 antigen.calcium.protein.vaccine

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MF59 Design and Evaluation of a Safe and Potent Adjuvant for Human Vaccines,ased on these weakly immunogenic antigens require an adjuvant for efficacy, we undertook the development of a safe and efficacious adjuvant suitable for widespread human administration. Vaccines formulated with aluminum salts (alum), the only adjuvant thus far utilized with vaccines approved in the

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Development of an Emulsion-Based Muramyl Dipeptide Adjuvant Formulation for Vaccines,ide) in an oil-inwater emulsion vehicle. The oil-in-water emulsion system contains squalane, Pluronic? LI21, and polysorbate 80 in an isotonic, pH 7.4, phosphate-buffered saline solution. This adjuvant elicits both cell-mediated and humoral immune responses. While threonyl-MDP serves to increase ant

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Lipid Matrix-Based Vaccines for Mucosal and Systemic Immunization,r a number of infectious diseases, vaccine formulations can still be improved in a number of important areas. The ability to induce antigen-specific humoral and cell-mediated immunity is crucial to the development of effective prophylactic and therapeutic vaccines. The approaches to the design of hu

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Polymer Microspheres for Vaccine Delivery,t blinded, mentally retarded, or severely crippled. The problem is most significant in developing countries where access to health care is poor. In these countries, it is estimated that more than half of the children who receive primary vaccinations do not complete their required booster immunizatio

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Vehicles for Oral Immunization,calized lymphoid tissue could stimulate IgA precursor cells that may then migrate to other mucosal surfaces (Craig and Cebra, 1971). Several oral vaccines have been shown to induce IgA responses at mucosal sites distal from that of the immunization, suggesting the feasibility of developing oral vacc

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Nanoparticles as Adjuvants for Vaccines,e the use of adjuvants to boost the immune response. Classical adjuvants include different kinds of emulsions, as well as aluminum derivatives such as aluminum hydroxide (Hem and White, 1984; and Chapter 9), aluminum phosphate (Hennessy ., 1971), and aluminum oxide (Grafe and Kuhn, 1962a,b). Aluminu