Titlebook: Vaccine Design; Methods and Protocol Sunil Thomas Book 2022Latest edition The Editor(s) (if applicable) and The Author(s), under exclusive

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Artificial Intelligence in Vaccine and Drug Designcent years. There has also been tremendous growth in the fields of data science, informatics, and artificial intelligence needed to handle this immense data flow. At the intersection of wet lab and data science is the field of bioinformatics, which seeks to apply computational tools to better unders

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Vaccines Targeting Numerous Coronavirus Antigens, Ensuring Broader Global Population Coverage: Multi time-consuming development of efficient anti-infectives and vaccines, the possible evolutionary adaptation of the virus to conventional vaccines, and the challenge to cover broad human population worldwide are the major reasons that made it challenging to avoid coronaviruses outbreaks. Although, a

Adherent

Use of Micro-Computed Tomography to Visualize and Quantify COVID-19 Vaccine Efficiency in Free-Breatdented proportions and rapidity causing over a million fatal cases. Recently, a robust Syrian golden hamster model recapitulating COVID-19 was developed in search for effective therapeutics and vaccine candidates. However, overt clinical disease symptoms were largely absent despite high levels of vi

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Techniques for Developing and Assessing Immune Responses Induced by Synthetic DNA Vaccines for Emergnd death caused by infectious agents. Traditional vaccine modalities including live-attenuated pathogen vaccines, wholly inactivated pathogen vaccines, and protein-based pathogen subunit vaccines have successfully been used to create efficacious vaccines against measles, mumps, rubella, polio, and y

Minikin

Towards Determining the Epitopes of the Structural Proteins of SARS-CoV-2auses severe diseases in humans and animals. The major structural proteins of SARS-CoV-2 include spike (S), envelop (E), membrane (M), and nucleocapsid (N). The current vaccines are based on the S protein. The emergence of variants of SARS-CoV-2 has renewed interest in the use of additional structur

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Development, Production, and Characterization of Hepatitis B Subviral Envelope Particles as a Third-e population vaccinated with the current S yeast-derived vaccine fail to induce an adequate immune response. Our group has developed a new-generation hepatitis B vaccine candidate composed by the three surface proteins of the HBV. Here we describe the methods to develop and characterize a stable CHO

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Generation of CpG-Recoded Zika Virus Vaccine Candidatesy lead to robust antiviral host immunity providing a cutting-edge approach for vaccines. For example, we have recently demonstrated that recoded Zika virus variants with the increased CpG content showed considerable attenuated infection phenotypes and protection against lethal challenge in mice. Her

Commodious

Salmonella Uptake into Gut-Associated Lymphoid Tissues: Implications for Targeted Mucosal Vaccine Deding viruses and bacteria, are sampled by the mucosal immune system. Antigen sampling occurs through M cells, a specialized epithelial cell type?located in the follicle-associated epithelium (FAE) that overlie Peyer’s patch lymphoid follicles. While Peyer’s patches play an integral role in intestina