Titlebook: Ubiquitin and the Biology of the Cell; Jan-Michael Peters,J. Robin Harris,Daniel Finley Book 1998 Springer Science+Business Media New York

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ed, and the importance of ubiquitin-dependent proteolysis as a regulatory mechanism gained general acceptance. The many strands of work that led to this new perception are re- counted in this book. A consequence of this progress is that the field has grown dramatically since the first book on ubiqui

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The Ubiquitin System,em, as an introduction to topics described in detail in the different chapters of this book; (2) to give to both the uninitiated and to the expert, but relatively newcomer ubiquitinologist a historical perspective on the discovery of the ubiquitin system, because much can be learned from the way in

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The 26 S Proteasome, about 30 different proteins. Fourteen subunits are provided by the proteasome and an additional 16 or more subunits are present in a particle that I will call the .. The 26 S enzyme is the only ATP-dependent protease so far identified in the nuclear and cytosolic compartments of eukaryotic cells—a

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Ubiquitin-Dependent Degradation of Transcription Regulators,gulation of transcription initiation. Transcription regulators are therefore among the main regulatory proteins in the cell. As such, control of their concentration—as well as their activity—has to be tightly regulated. Rapid modulation of the concentration of a protein requires it to be relatively

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,Role of the Ubiquitin—Proteasome Pathway in NF-κB Activation,nt reviews see Verma ., 1995; Finco and Baldwin, 1995; Thanos and Maniatis, 1995; Siebenlist ., 1994; Baeuerle and Henkel, 1994). Both subunits of NF-κB (p50 and p65) are members of the Rel family of transcriptional activator proteins, but they differ in their modes of synthesis. The p65 subunit of