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Titlebook: Ubiquitin Chains: Degradation and Beyond; Arnab De Book 2015 Springer International Publishing Switzerland 2015 NF-κB signaling.adaptive r

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發(fā)表于 2025-3-21 17:16:31 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
書目名稱Ubiquitin Chains: Degradation and Beyond
編輯Arnab De
視頻videohttp://file.papertrans.cn/941/940213/940213.mp4
概述Nominated as an outstanding Ph.D. thesis by Columbia University, New York, USA.Insightful and in-depth evaluation of the evidence for K63-linked regulatory ubiquitination in regulating cell-signalling
叢書名稱Springer Theses
圖書封面Titlebook: Ubiquitin Chains: Degradation and Beyond;  Arnab De Book 2015 Springer International Publishing Switzerland 2015 NF-κB signaling.adaptive r
描述This thesis examines the evidence for regulatory ubiquitination by focusing on A20. It provides an insightful and in-depth evaluation of the current literature by critically examining the evidence of K63-linked regulatory ubiquitination in regulating cell-signalling. It is also the first thesis to directly test the role of regulatory ubiquitination in NF-kB signaling .in vivo.. The case for regulatory ubiquitination has been to a large extent predicated upon the presumed deubiquitinase activity of A20, long considered a key regulator of inflammatory responses as mice lacking A20 die from multi-organ inflammation and cachexia. The theses reports the creation and characterization of a knock-in mouse that expresses a mutated form of A20 which selectively lacks the deubiquitinase activity. The knock-in mice surprisingly display completely normal NF-κB activation with no accompanying inflammatory phenotype. Given that the presumed role of A20 as a deubiquitinase has been used to support the importance of regulatory K63-linked ubiquitination in NF-kB signaling, this study will help focus future research efforts into alternative target pathways that do not depend on K63 ubiquitination. In
出版日期Book 2015
關(guān)鍵詞NF-κB signaling; adaptive response; innate immunity; pattern-recognition receptors; regulatory ubiquitin
版次1
doihttps://doi.org/10.1007/978-3-319-14965-3
isbn_softcover978-3-319-38534-1
isbn_ebook978-3-319-14965-3Series ISSN 2190-5053 Series E-ISSN 2190-5061
issn_series 2190-5053
copyrightSpringer International Publishing Switzerland 2015
The information of publication is updating

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發(fā)表于 2025-3-21 20:32:08 | 只看該作者
https://doi.org/10.1007/978-3-319-14965-3NF-κB signaling; adaptive response; innate immunity; pattern-recognition receptors; regulatory ubiquitin
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Ubiquitin Chains: Degradation and Beyond978-3-319-14965-3Series ISSN 2190-5053 Series E-ISSN 2190-5061
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發(fā)表于 2025-3-22 11:52:28 | 只看該作者
Arnab DeNominated as an outstanding Ph.D. thesis by Columbia University, New York, USA.Insightful and in-depth evaluation of the evidence for K63-linked regulatory ubiquitination in regulating cell-signalling
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發(fā)表于 2025-3-22 13:41:44 | 只看該作者
2190-5053 nked regulatory ubiquitination in regulating cell-signallingThis thesis examines the evidence for regulatory ubiquitination by focusing on A20. It provides an insightful and in-depth evaluation of the current literature by critically examining the evidence of K63-linked regulatory ubiquitination in
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