| 書(shū)目名稱 | Tubulin-Binding Agents | | 副標(biāo)題 | Synthetic, Structura | | 編輯 | Teresa Carlomagno | | 視頻video | http://file.papertrans.cn/931/930753/930753.mp4 | | 概述 | This series presents critical reviews of the present position and future trends in modern chemical research.Short and concise reports on chemistry, each written by the world renowned experts.Still val | | 叢書(shū)名稱 | Topics in Current Chemistry | | 圖書(shū)封面 |  | | 描述 | reviews. The SAR data are discussed in light of the structural information available for each agent. The second chapter focuses on the total synthesis of the marine sponge-derived polyketide discodermolide. A comprehensive survey of the synthetic chemistry efforts of several groups over a 14-year period is provided together with a compa- son of the different approaches. The third chapter describes a comprehensive study of the mechanisms of activity of microtubules stabilizing drugs. Thermodynamic, kinetic, structural and fu- tional data on microtubules stabilizing drugs are discussed in an interdisciplinary manner to generate a “time-resolved” picture of the interaction of the drugs with different tubulin forms. The fourth and fifth chapters review the efforts and achievements made in the characterization of the structure of the complexes of tubulin with microtubules stabilizing agents by NMR (Chapter 4) and EM (Chapter 5). Especially evident is the discrepancy of the results obtained for epothilones, where the two techniques deliver radically different structures of the bound drug. Both NMR and EM models are, however, able to explain a consistent set of SAR data. The authors of th | | 出版日期 | Book 2009 | | 關(guān)鍵詞 | Biochemistry; Destabilizing Agents; Microtubules; Stabilizing Agents; Tubulin-Binding Agents; chemistry; m | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-540-69039-9 | | isbn_softcover | 978-3-642-43594-2 | | isbn_ebook | 978-3-540-69039-9Series ISSN 0340-1022 Series E-ISSN 1436-5049 | | issn_series | 0340-1022 | | copyright | Springer-Verlag Berlin Heidelberg 2009 |
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