| 書目名稱 | The T-Cell Receptors | | 編輯 | Tak W. Mak | | 視頻video | http://file.papertrans.cn/921/920917/920917.mp4 | | 圖書封面 |  | | 描述 | The importance of thymus-dependent cells, or T cells, in the generation of a successful immune response was first realized in the early sixties. In the follow- ing two decades, a succession of elegant experiments established the antigen specificity of T cells and their ability to perform both as regulatory and effector cells. T cells were shown to be essential in most immune reactions, playing a crucial role in augmenting the activity of effector T and B cells against ‘foreign‘ antigen, as well as in the suppression of effector activity against self antigens. The means by which T cells differentiate ‘foreign‘ from ‘self‘ antigens is based on their recognition of antigen almost exclusively in the context of self major histocompatibility complex products, unlike B cells, which recognize an- tigen alone. It is this recognition, mediated by the T-cell receptor, that sets into motion the diverse cell-cell interactions, which control the differentiation and regulation of the immune response. Although its importance was well established, the molecular nature of the T-cell receptor remained elusive for two decades. Many hypotheses as to its structure and precise function were put forward, | | 出版日期 | Book 1988 | | 關鍵詞 | Antigen; T cell; Thymus; evolution; growth; histocompatibility; immunoglobulin; leukemia; lymphocytes; parasi | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-4684-5406-2 | | isbn_softcover | 978-1-4684-5408-6 | | isbn_ebook | 978-1-4684-5406-2 | | copyright | Plenum Press, New York 1988 |
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