| 書(shū)目名稱 | The Inflammasome | | 副標(biāo)題 | Methods and Protocol | | 編輯 | Christine M. De Nardo,Eicke Latz | | 視頻video | http://file.papertrans.cn/912/911978/911978.mp4 | | 概述 | Presents current up-to-date methodologies.Provides step-by-step detail essential for reproducible results.Contains key notes and implementation advice from the experts.Includes supplementary material: | | 叢書(shū)名稱 | Methods in Molecular Biology | | 圖書(shū)封面 |  | | 描述 | .?Inflammasomes have a seemingly simple architecture. A sensor molecule of the NLR or PYHIN protein family recruits the common adapter molecule apoptosis-associated speck-like protein containing a CARD (ASC). Even so, inflammasome activation is highly regulated at multiple steps and precise details of how inflammasomes are activated at the molecular level remain largely unknown. In .The Inflammasome: Methods and Protocols., expert researchers in the field detail methods and protocols to study multiple aspects of inflammasome function. These methods include the generation of inflammasome stimuli, perturbance of cellular homeostasis, assessment of ASC speck formation, monitoring of caspase-1 activity and processing, activation of IL-1β cytokines, and analysis of inflammasome assembly. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.. | | 出版日期 | Book 2013 | | 關(guān)鍵詞 | ATP binding; ATPase activity; Cells; NLRP3 stimulating Amyloid beta; adjuvants; cellular homeostasis; crys | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-62703-523-1 | | isbn_softcover | 978-1-4939-6011-8 | | isbn_ebook | 978-1-62703-523-1Series ISSN 1064-3745 Series E-ISSN 1940-6029 | | issn_series | 1064-3745 | | copyright | Springer Science+Business Media New York 2013 |
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