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Titlebook: The Future of Predictive Safety Evaluation; In Two Volumes Volum A. N. Worden,D. V. Parke,J. Marks Book 1987 MTP Press Limited 1987 cancer.

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書目名稱The Future of Predictive Safety Evaluation
副標(biāo)題In Two Volumes Volum
編輯A. N. Worden,D. V. Parke,J. Marks
視頻videohttp://file.papertrans.cn/911/910220/910220.mp4
圖書封面Titlebook: The Future of Predictive Safety Evaluation; In Two Volumes Volum A. N. Worden,D. V. Parke,J. Marks Book 1987 MTP Press Limited 1987 cancer.
描述Reproduction and fetal development in humans and experimental animals may be adversely affected by a wide range of drugs and environmental agents. They may be toxic in the parental generation leading to impaired germ cell formation, loss of reproductive poten- tial and infertility following chronic exposure. Deviant fetal development occurs as a consequence of cellular damage at sensi- tive stages in development. Changes seen range from intrauterine mortality and structural malformation to growth retardation with physiological and behavioural defects. Concepts on the mechanism of action of teratogens are discussed with reference to some better-known agents. Presently, regulatory authorities prefer whole animal studies in predictive safety evaluation of substances to which a pregnant woman may be exposed. Tests are conducted over one or more generations and are designed to study the influence of test com- pounds upon general reproductive performance, fertility, fetal development and perinatal and postnatal behaviour. Experiments are designed to permit compounds to be tested under conditions resembling expected human exposure. Small rodents and rabbits are preferred species on accoun
出版日期Book 1987
關(guān)鍵詞cancer; clinical trial; drug; drug safety; neurotoxicity; research; toxicity; toxicology
版次1
doihttps://doi.org/10.1007/978-94-009-3201-2
isbn_softcover978-94-010-7936-5
isbn_ebook978-94-009-3201-2
copyrightMTP Press Limited 1987
The information of publication is updating

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978-94-010-7936-5MTP Press Limited 1987
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Book 1987y may be toxic in the parental generation leading to impaired germ cell formation, loss of reproductive poten- tial and infertility following chronic exposure. Deviant fetal development occurs as a consequence of cellular damage at sensi- tive stages in development. Changes seen range from intrauter
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gents. They may be toxic in the parental generation leading to impaired germ cell formation, loss of reproductive poten- tial and infertility following chronic exposure. Deviant fetal development occurs as a consequence of cellular damage at sensi- tive stages in development. Changes seen range from
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Communitarian Happiness,ppy as long as it itself is. Our constituent parts constantly leave us, our hair when we have a haircut, our nails when we cut them. Do we have an obligation to make sure that our constituent parts are as happy as possible even after they leave our dominion? And, of course, the great majority of our
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,Empirie — Schriftliche Befragung, literature on multi-stage games in assuming that if the government can commit then it commits to the same environmental standard no matter what the subsequent location decisions of firms turn out to be (we call this simple commitment). But in principle a government could commit to a policy rule, wh
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,St?dtetypologien und -klassifikationen,Zur Unterstützung des Projektmanagements, also der Planung, Steuerung, Koordination und überwachung von Projekten, werden graphentheoretische Methoden erfolgreich eingesetzt, wobei die Netzplantechnik eine zentrale Rolle spielt.
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