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Titlebook: The Epothilones: An Outstanding Family of Anti-Tumor Agents; From Soil to the Cli K.- H. Altmann,G. H?fle,K. Prantz Book 2009 Springer-Verl

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書目名稱The Epothilones: An Outstanding Family of Anti-Tumor Agents
副標題From Soil to the Cli
編輯K.- H. Altmann,G. H?fle,K. Prantz
視頻videohttp://file.papertrans.cn/909/908907/908907.mp4
概述Includes supplementary material:
叢書名稱Fortschritte der Chemie organischer Naturstoffe‘ Progress in the Chemistry of Organic Natural Produc
圖書封面Titlebook: The Epothilones: An Outstanding Family of Anti-Tumor Agents; From Soil to the Cli K.- H. Altmann,G. H?fle,K. Prantz Book 2009 Springer-Verl
描述Epothilones have received unusual attention over the past ten years. They are novel antitumor drugs which very much like their predecessor paclitaxel (Taxol) act via microtubule stabilization. In comparison to paclitaxel and a number of alternative drugs with a similar mode of bioaction (e.g. laulimalide, eleutherobin, peluroside, discodermolide) the epothilones have significant advantages, above all very high activity in the nanomolar range and low susceptibility towards multidrug resistance. Epothilone B and several derivatives thereof are in phase I-III clinical trials; one of them (ixabepilone, BMS) is already on the market, others are supposed to appear on the market in the near future. All naturally occurring epothilones have been isolated from Sorangium cellulosum; their antitumor action is traced back to the stabilization of microtubules. In consequence, the formation of the mitototic spindle is prohibited and the cell undergoes apoptosis.
出版日期Book 2009
關(guān)鍵詞Expression; anti-tumour agent; anti-tumour drug; apoptosis; biochemistry; chemistry; epothilone; genetic en
版次1
doihttps://doi.org/10.1007/978-3-211-78207-1
isbn_softcover978-3-211-99928-8
isbn_ebook978-3-211-78207-1Series ISSN 0071-7886
issn_series 0071-7886
copyrightSpringer-Verlag Vienna 2009
The information of publication is updating

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