| 書目名稱 | Targeting Notch in Cancer | | 副標(biāo)題 | From the Fruit Fly t | | 編輯 | Lucio Miele,Spyros Artavanis-Tsakonas | | 視頻video | http://file.papertrans.cn/901/900639/900639.mp4 | | 概述 | Comprehensive coverage of Notch in Cancer that will leave the reader with an up-to-date understanding of the topic.Provides the reader not only with historical and current research but also extrapolat | | 圖書封面 |  | | 描述 | .The serendipitously discovered link between developmental biology and cancer, touched of an explosion of discoveries on the role of Notch in human malignancies, including every aspect of cancer biology, from control of differentiation, proliferation and apoptosis in transformed cells to angiogenesis, tumor-stroma interaction and anti-cancer immune responses. A number of observations have revealed that Notch even plays a role in the renewal of cancer stem cells and tumor initiating cells, which are thought to be a major cause of resistance to treatment. .Targeting Notch in Cancer .will provide researchers, oncologists, pharmacologists and students with a detailed understanding of the intricate cross-talk between Notch and other pathways of therapeutic interest so to better design rational drug combinations for specific diseases and disease subsets...Divided into two parts, Part I describes in detail what we know about the genetics, molecular biology, biochemistry andstructural biology of Notch, as well as the role of Notch in such processes as angiogenesis and immune surveillance. Without insights gained from these basic studies, rational targeting of Notch in human disease would b | | 出版日期 | Book 2018 | | 關(guān)鍵詞 | Cancer; Drosophila Notch; Notch; TAN-1; chromosome 7 | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-4939-8859-4 | | isbn_ebook | 978-1-4939-8859-4 | | copyright | Springer Science+Business Media, LLC, part of Springer Nature 2018 |
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