Titlebook: Synthesis of Therapeutic Oligonucleotides; Satoshi Obika,Mitsuo Sekine Book 2018 Springer Nature Singapore Pte Ltd. 2018 Therapeutic oligo

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Various Coupling Agents in the Phosphoramidite Method for Oligonucleotide Synthesisthe most widely employed method for the chemical synthesis of oligodeoxyribonucleotides and oligoribonucleotides, and it describes their utility, efficiency, and drawbacks. Moreover, the mechanism of the coupling of the nucleoside phosphoramidite and nucleoside promoted by the coupling agent is disc

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itinerary

Liquid-Phase Synthesis of Oligonucleotidest applies our original liquid-phase synthesis technology for practical use..Recent progress in various types of oligonucleotide therapeutics, such as antisense, aptamer, siRNA and miRNA, has led to growing demand for economical and/or large scale production. Conventionally-known solid-phase synthesi

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Nucleosides and Oligonucleotides Incorporating 2-Thiothymine or 2-Thiouracil Derivatives as Modifiedinity and base discrimination ability. For the incorporation of these thio-bases into oligonucleotides, efficient methods for the synthesis of thio-modified nucleosides and the incorporation of the thio-nucleosides into oligonucleotides under solid-phase conditions are necessary. In this chapter, th

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Four-Hydrogen-Bonding Base Pairs in Oligonucleotides: Design, Synthesis, and Propertiesion have been designed and prepared to address the fundamental question: why did Watson–Crick base pairs come to contain two or three H-bonds during the evolution of life? As the first generation of four-H-bonding base pairs, imidazo[5′,4′:4,5]pyrido[2,3-.]pyrimidine (.) was selected as an aglycon t

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Photo-Cross-Linkable Artificial Nucleic Acid: Synthesis and Properties of 3-Cyanovinylcarbazole-Modimporally due to its sequence specificity and high photo irradiation operability. Therefore, photo-cross-linkable artificial nucleic acids are required to be specific and effective drugs without adverse effects and also be good tools for investigating gene functions in cells..As one of the most react