Titlebook: Stem Cell Therapy for Diabetes; Shimon Efrat Book 2010 Humana Press 2010 Diabetes.Immunity.Pancreas.Regulation.Tissue Engineering.cell bio

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Prevention of Islet Graft Rejection and Recipient Tolerization hyperglycemia. Adaptive immune mechanisms are believed to be primary mediators of this process. Immune memory for the initial process that resulted in β-cell failure, the high frequency of alloreactive T cells, and the nonphysiologic environment into which islets have been transplanted all create o

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Book 2010 and ways for cell protection from recurring autoimmunity and graft rejection. Stem Cell Therapy for Diabetes provides essential reading for those especially interested in tracking the progress in applying of one of the most exciting new developments in bio-medicine towards a cure for diabetes..

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What Does It Take to Make a Beta Cell?hapter is written with an eye toward how β cells, or some kind of β-cell surrogate, might function when transplanted. It is important to understand β cells in their normal pancreatic environment to fully appreciate the compromises that will necessarily accompany β-cell replacement therapy.

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Generation of Beta Cells from Pancreatic Duct Cells and/or Stem Cellsical reason for there to be only one mechanism for replenishment of the islet cells. This chapter focuses on the renewed interest in the identification, expansion, and differentiation of adult pancreatic progenitor/stem cells that can lead to more β cells, either in vivo or in vitro.

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Functional Tissue Reconstruction with the Use of Biologic Scaffoldsng methods upon the structural properties and resulting mechanical behavior of the scaffold materials, and the in-vivo degradation and remodeling of ECM scaffolds. Finally, the potential application of ECM scaffold materials to regeneration of endocrine tissues is discussed.

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Prevention of Islet Graft Rejection and Recipient Tolerizationbstacles for successful reversal of diabetes with islet replacement. In this chapter we review the immune mechanisms that are thought to be responsible for β-cell destruction and discuss the obstacles that stand in the way of the successful achievement of β-cell replacement.

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trie. Diese Zurückhaltung findet ihre Grundlage in der Betonung von prognostischen und sicherheitsbezogenen Aspekten bei der Behandlung von Ma?regelvollzugspatienten. Erst unter der Voraussetzung, dass ausführliche Studienergebnisse unabh?ngig voneinander einen eindeutigen Vorteil einer solchen Vorg

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George K. Gittes,Krishna Prasadan,Sidhartha Tulachantrie. Diese Zurückhaltung findet ihre Grundlage in der Betonung von prognostischen und sicherheitsbezogenen Aspekten bei der Behandlung von Ma?regelvollzugspatienten. Erst unter der Voraussetzung, dass ausführliche Studienergebnisse unabh?ngig voneinander einen eindeutigen Vorteil einer solchen Vorg