| 書目名稱 | Signaling Pathways in Cancer Pathogenesis and Therapy | | 編輯 | David A. Frank | | 視頻video | http://file.papertrans.cn/868/867172/867172.mp4 | | 概述 | Explores novel therapeutic strategies to inhibit signaling.Discusses current and next generation antimitotic therapies in cancer.Features up-to-date research.Includes supplementary material: | | 圖書封面 |  | | 描述 | .In recent years, increasing evidence has suggested that abnormal activation of signaling pathways is a critical event in cancer pathogenesis. In particular, activation of these pathways can lead to inappropriate cellular survival, proliferation, pluripotency, invasion, metastasis, and angiogenesis. Thus, understanding the mechanisms by which signaling pathways become subverted in a cancer cell can provide insight into critical events in cancer pathogenesis. Furthermore, as our ability to target specific molecular interactions advances, we now have the ability to design small molecules, protein therapeutics, and other forms of targeted therapies. By focusing on the specific molecular abnormalities in a cancer cell, these agents hold the potential to be much more effective and much less toxic than current cytotoxic therapies.. | | 出版日期 | Book 20121st edition | | 關(guān)鍵詞 | DNA damage; Nonreceptor Tyrosine Kinases; STAT signaling; Wnt signaling; hedgehog signaling pathway | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-4614-1216-8 | | isbn_softcover | 978-1-4899-9222-2 | | isbn_ebook | 978-1-4614-1216-8 | | copyright | Springer Science+Business Media, LLC 2012 |
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