Titlebook: Sigma Receptors: Their Role in Disease and as Therapeutic Targets; Sylvia B. Smith,Tsung-Ping Su Book 2017 Springer International Publishi

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,The Evolution of the Sigma-2 (σ,) Receptor from Obscure Binding Site to , Therapeutic Target,o binding studies over 25 years ago, the molecular identity of this protein is currently not unambiguously known, and the results from recent attempts to identify the σ. receptor through protein purification and mass spectral analysis have been the subject of debate in the literature. However, there

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Pharmacological Modulation of the Sigma 1 Receptor and the Treatment of Pain,ies and reduce their unwanted effects. Current preclinical evidence supports the modulatory role of sigma-1 receptors (σ.R) in nociception, mainly based on the pain-attenuated phenotype of σ.R knockout mice and on the antinociceptive effect exerted by σ.R antagonists on pains of different etiologies

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Sigma-1 Receptors and Neurodegenerative Diseases: Towards a Hypothesis of Sigma-1 Receptors as Ampldiseases. Accumulating evidence indicates that sigma-1 ligands can either directly or indirectly modulate multiple neurodegenerative processes, including excitotoxicity, calcium dysregulation, mitochondrial and endoplasmic reticulum dysfunction, inflammation, and astrogliosis. In addition, sigma-1 l