Titlebook: Sickle Cell Disease and Hematopoietic Stem Cell Transplantation; Emily Riehm Meier,Allistair Abraham,Ross M. Fasano Book 2018 Springer Int

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Risk-Based Therapies for Sickle Cell Diseasempared to patients with HbSC or HbSβ.thalassemia. However, clinical complications vary dramatically, even among patients with the same genotype. One of the most fascinating and frustrating aspects of sickle cell care is how people with the same single amino acid substitution can have different clini

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Transfusion Support of the Patient with Sickle Cell Disease Undergoing Transplantation is the only curative therapy to date. Complications of transfusion therapy, including alloimmunization and iron overload, may potentially impact curative future HSCT. These sequelae may influence decisions relating to hematopoietic stem cell (HSC) donor selection, the level of conditioning regimen

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Neurological Manifestations of Sickle Cell Disease and Their Impact on Allogeneic Hematopoietic Stemren with sickle cell anemia (SCA) historically have had higher stroke risk than any other group of children outside of the perinatal period. Overt strokes are widely accepted as an indication for curative allogeneic hematopoietic stem cell transplantation (HSCT). As we learn more about the broad spe

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Unique Challenges of Hematopoietic Stem Cell Transplant for Sickle Cell Diseasestem cell transplant. These include a relative paucity of fully matched unrelated donors compared to other underlying indications for transplant, an increased risk for neurovascular complications and sequelae related to existing endothelial dysfunction. As transplant conditioning regimens are being

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The Ethics of Hematopoietic Stem Cell Transplantation for Sickle Cell Diseaseanswers. Five such important questions include: (1) Should HSCT be offered to children with less severe SCD? (2) Should assisted reproductive technology be used to conceive sibling donors? (3) Should HSCT be offered to children with significant social concerns? (4) Should children from low-income co

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Matched Sibling Donor Hematopoietic Stem Cell Transplantation for Sickle Cell DiseaseThe worldwide experience with HSCT for sickle cell disease is predominantly with matched-related donors (MRDs). Conditioning regimens have historically been myeloablative, still considered by many to be standard of care when HSCT is performed for this disease. Efforts are underway to reduce the acut

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