Titlebook: Serpins; Methods and Protocol Alexandra Lucas Book 2018 Springer Science+Business Media, LLC, part of Springer Nature 2018 Serine protease

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Annamaria Fra,Emanuela D’Acunto,Mattia Laffranchi,Elena Miranda

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Overview of Serpins and Their Roles in Biological Systems,resent in all kingdoms and often regulating central pathways for clotting, immunity, and even cancer in man. Serpins have been present from the time of the dinosaurs and can represent a large proportion of circulating blood proteins. With this introductory chapter, we present an overview of serpins

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Methods for Determining and Understanding Serpin Structure and Function: X-Ray Crystallography,n and inhibitory mechanisms. In addition, high-resolution structural information of serpins derived from the three domains of life (bacteria, archaea, and eukaryotic) and viruses has provided valuable insights into the hereditary and evolutionary history of this unique superfamily of proteins. This

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Methods for Identifying Virus-Derived Serpins,ce of mammalian proteases to facilitate virus replication in the infected host. DNA viruses, in particular members of the poxvirus family, have acquired multiple copies of the functional serpins which are essential for viral pathogenesis. Virus-encoded serpins have proven to be very effective inhibi

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Binding of Serpins to Immobilized Phospholipids and Phospholipids in Suspension,itory activity and—at least in the case of SERPINA5—to mediate serpin internalization into cells. Also phospholipid functions may be altered when bound to serpins or other proteins..By interacting with phospholipids, serpins might influence a variety of cellular functions. Binding of proteins to pho