Titlebook: Scher and Daniel‘s Nails; Diagnosis, Surgery, Adam I. Rubin,Nathaniel J. Jellinek,Richard K. Sch Textbook 2018Latest edition Springer Inte

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Nail Unit Lichen Planus,cceptance of therapy. Treatment of nail LP is difficult, as not all patients respond to therapy. Optimal therapy is still lacking, and systemic or intralesional steroids (the choice is based on the numbers of nails involved) are the treatment of choice.

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Onychomycosis: Clinical Aspects,y cover the whole nail plate. Proximal subungual onychomycosis is rare and begins in the stratum corneum, infecting the proximal nail plate and lunula. The infection moves distally and generally remains in the deeper layers of the nail. Endonyx onychomycosis also begins in the hyponychium; however,

spinal-stenosis

Onychomycosis: Laboratory Methods,lly, the importance of proper laboratory diagnosis of onychomycosis to the success of clinical trials of novel antifungals is discussed, with an emphasis on the role of negative microscopy in the definition of mycological cure.

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Melanonychia,ndicative of melanoma. Treatment of early subungual melanoma is by wide local excision of the entire nail organ with 6 mm around the anatomic border and 10 mm around Hutchinson’s sign. Advanced ungual melanoma still requires distal amputation. All brown and black nail pigmentations have to be consid

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Non Melanocytic Pigment Abnormalities,nterpretation by the dermatopathologist. In this chapter, a systematic approach to the physical examination and subsequent decision-making will be discussed as means by which to distinguish non-melanocytic from melanocytic causes of nail pigmentation.

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Michael J. Passananteght the infection and secretion of cytokines and chemokines for cell–cell communication. The complement system is an ancient system of proteins for fighting infections. Once activated, complement proteins promote inflammation and directly kill pathogens. Other effector mechanisms such as the secreti

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Nathaniel J. Jellinek,Adam I. Rubin as ligands, the T cell receptor binds to peptides presented on the cell surface by proteins of the major histocompatibility complex (MHC), named HLA proteins in humans. One advantage of the MHC system is that CD8 killer T cells can recognize and destroy host cells infected by an intracellular patho