Titlebook: Rodent Quality Control: Genes and Bugs; Monitoring Health an Fernando Benavides,Axel Kornerup Hansen Book 2024 The Editor(s) (if applicable

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Genetically Standardized Laboratory Rodents, a specific focus on the mouse (.) and the rat (.), the predominant species utilized in biomedical research. We include fundamental information on various genetically standardized strains, with a primary emphasis on inbred strains and their derivatives. The production and maintenance processes of th

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Genetically Altered Rodents,ologies for generating genetically modified animals have emerged over the years, with mice and rats standing out as premier models. Initial methods involved pronuclear microinjection of DNA fragments into one-cell embryos, resulting in approximately 10% of the offspring carrying the transgene. More

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Standard Nomenclature of Mouse and Rat Strains, on standardized genetic nomenclature for mice and rats. The accurate designation and communication among researchers working with laboratory strains center on these rules, establishing connections between strains and their origin and history. Emphasizing fundamental principles, this chapter undersc

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Genetic Quality Controls for Inbred Strains and Outbred Stocks,imal facilities. In addition to health and microbiology monitoring, genetic quality control plays a crucial role in ensuring the accuracy of animal models. Therefore, it is essential that research studies utilizing laboratory rodents, particularly mice and rats, employ genetically defined animals. T

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Cryopreservation of Valuable Mouse and Rat Lines,tandard procedure applied in many rodent facilities and large repositories around the world. Slow freezing was the first methodology developed for embryo cryopreservation and is still suitable and reliable. Despite this, the ultra-rapid vitrification technique is gaining more adepts since it is fast

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Health Monitoring Programmes and International Standards,d reproducible results from animal experimentation. A proper health monitoring program must be established in order to evaluate the efficiency of hygienic measures. To obtain optimal information from testing, all the critical variables must be taken into account, and all the procedures need to be ad

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Statistical Aspects of Health Monitoring in Rodents,ion of animals that it is reasonable to assume, that this specific agent will infect in the colony, and the sensitivity of the assay, i.e., how the fraction of the infected animals are likely to become positive in the assay. In smaller colonies, the size of the colony also has an impact on the sampl

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