| 書目名稱 | Ribonuclease P | | 編輯 | Fenyong Liu,Sidney Altman | | 視頻video | http://file.papertrans.cn/831/830168/830168.mp4 | | 概述 | Will cover a broad range of subjects in RNA research, including: structural analysis by biochemical or biophysical means; m. RNA structure, function and biogenesis; ribosome structure and function; tr | | 叢書名稱 | Protein Reviews | | 圖書封面 |  | | 描述 | The Discovery of Ribonuclease P and Enzymatic Activity of Its RNA Subunit Sydney Brenner and Francis H. C. Crick had a specific project in mind when they offered Sidney Altman a position in their group in 1969 to conduct postdoctoral research at the Medical Research Council Laboratory of Molecular Biology (LMB) in Cambridge, England. At the time, an intense international competition was on- ing in as many as a dozen labs to determine the three-dimensional structure of tRNA. At the LMB, Aaron Klug was attacking the structure by crystallographic analysis with Brian F. C. Clark providing large amounts of purified phenylalanine tRNA. (Eventually, Aaron announced his empirically determined 3-D structure of yeast phenylalanine tRNA, a structure that is generally common to tRNAs, due in part to several conserved, novel three-way nucleotide interactions. ) Concurrently, Michael Levitt, a Ph. D. student of Francis, was visually scrutinizing the cloverleaf secondary structure of the 14 tRNA sequences known at the time. Levitt was searching for nucleotide covariation in different parts of the molecules that were conserved in the 14 sequences known at the time. He identified a possible covaria | | 出版日期 | Book 2010 | | 關(guān)鍵詞 | RNA; biochemistry; enzymes; liu; ribonuclease; rnase p; transcription; translation; Proteomics | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-4419-1142-1 | | isbn_softcover | 978-1-4614-2573-1 | | isbn_ebook | 978-1-4419-1142-1 | | copyright | Springer-Verlag New York 2010 |
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