| 書目名稱 | Rho GTPases | | 副標(biāo)題 | Methods and Protocol | | 編輯 | Francisco Rivero | | 視頻video | http://file.papertrans.cn/831/830136/830136.mp4 | | 概述 | Includes cutting-edge methods and protocols.Provides step-by-step detail essential for reproducible results.Contains key notes and implementation advice from the experts | | 叢書名稱 | Methods in Molecular Biology | | 圖書封面 |  | | 描述 | .Although initially described as major regulators of cytoskeletal remodeling, Rho GTPases have been implicated in the establishment of polarity, endocytosis, vesicle trafficking, morphogenesis, cytokinesis, transcriptional activation, cell cycle progression, and apoptosis, to mention a few. In addition, Rho GTPases have acquired medical relevance because of their participation in tumorigenesis and metastasis, in cardiovascular conditions, and as targets of infectious agents. The field has broadened even more with the contribution of studies in model organisms (plants, amoebas, fungi, invertebrates), each adding a particular view to the complexity of the family and vastly enriching our perception of these important signaling components. Divided into five convenient sections, .Rho GTPase: Methods and Protocols. provides an historical overview of the field and an account of the phylogenetics of the Rho family, general biochemical methods, and functional assays that allow monitoring the consequences of manipulating Rho GTPases in a variety of contexts. Additionally, the volume devotes a section to advanced imaging methods and to recently developed high throughput methods, closing with | | 出版日期 | Book 2012 | | 關(guān)鍵詞 | Cdc42; Rac; Rho GDI; Rho GTPases signaling; complex protein family | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-61779-442-1 | | isbn_softcover | 978-1-4939-5896-2 | | isbn_ebook | 978-1-61779-442-1Series ISSN 1064-3745 Series E-ISSN 1940-6029 | | issn_series | 1064-3745 | | copyright | Springer Science+Business Media, LLC 2012 |
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