Titlebook: Reviews on New Drug Targets in Age-Related Disorders; Paul C. Guest Book 2020 The Editor(s) (if applicable) and The Author(s), under exclu

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https://doi.org/10.1007/978-3-030-42667-5age-related diseases; parabiosis; bioactive lipids; Alzheimer’s disease; Metformin; Proteomics; Metabolomi

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Micronutrients that Affect Immunosenescence,oor nutritional status predisposes to certain infections. Immune function may be ameliorated by restoring deficient micronutrients to recommended levels, thereby increasing resistance to infection and supporting faster recovery when infected. This review looks at the effects of micronutrient supplementation on immune function during aging.

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Effect of Short Chain Fatty Acids on Age-Related Disorders,fications in their intestinal levels are associated with development of age-related pathologies including metabolic diseases and type 2 diabetes, hypertension, cardiovascular and neurodegenerative diseases. We also highlight their impact on the development of cancer.

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The Role of Nutrition in Attenuating Age-Related Skeletal Muscle Atrophy,l, hormonal, and pharmacological approaches have been attempted to attenuate sarcopenia but these have not achieved outstanding results. In this review, we summarize the current knowledge of nutrition-based therapies for counteracting sarcopenia.

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,Early Diagnosis and Targeted Treatment Strategy for Improved Therapeutic Outcomes in Alzheimer’s Diion of biomarker tests for diagnosis during the prodromal or early stages of the disease. In addition, it is proposed that targeting specific components of the amyloid deposition, tau oligomerization and neuroinflammation pathways may lead to improved outcomes in clinical studies.

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Micronutrients that Affect Immunosenescence, to infection in the elderly. In addition to intrinsic alterations in the immune system with aging, the elderly are more likely to have poor nutritional status, which further affects the already impaired immune function. Micronutrient deficiencies are a recognized global public health problem, and p

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Bioactive Lipids in Age-Related Disorders,type 2 diabetes mellitus, hypertension, atherosclerosis, coronary heart disease, immune dysfunction and cancer. It has been noted that in all these disorders there could occur a defect in the activities of desaturases, cyclo-oxygenase (COX), and lipoxygenase (LOX) enzymes leading to a decrease in th

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