Titlebook: Reviews of Physiology, Biochemistry and Pharmacology; S. G. Amara,E. Bamberg,M. Schweiger Book 2003 The Editor(s) (if applicable) and The

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Crayon

Signal recognition particle-depencent protein targeting, universal to all kingdoms of life,intricate assembly process. The preferential substrates of SRP possess especially hydrophobic signal sequences. Interactions between SRP and its receptor, the ribosome, the signal sequence, and the target membrane are regulated by GTP hydrolysis. SRP-dependent protein targeting in bacteria and chlor

Foregery

Transport of organic anions across the basolateral membrane of proximal tubule cells,(OAT1) cloned from several species was shown to exchange extracellular OA against intracellular α-ketoglutarate. OAT1 translocated, e.g., anti-inflammatory drugs, antiviral drugs, β-lactam antibiotics, loop diuretics, ochratoxin A, and .-aminohippurate. Several OA, including probenecid, inhibited OA

類型

Molecular basis of skeletal muscle plasticity-from gene to form and function,nscriptional adaptations in skeletal muscle due to changes in loading involve a broad range of genes and that mRNA changes often run parallel for genes in the same functional categories. These changes can be matched to the structural/functional adaptations known to occur with corresponding stimuli.

ethnology

,Tumour-inhibiting platinum complexes—state of the art and future perspectives,yclohexane (DACH) and on the promising and more recently evolving field of non-classic (.- and multinuclear) platinum complexes. The development of oral platinum drugs and drug targeting strategies using liposomes, polymers or low-molecular-weight carriers in order to improve the therapeutic index of platinum chemotherapy are also covered.

突襲

,Tumour-inhibiting platinum complexes—state of the art and future perspectives,ve field of research. This article reviews the current preclinical and clinical status, including a discussion of the molecular basis for the activity of the parent drug cisplatin and platinum drugs of the second and third generation, in particular their interaction with DNA. Further emphasis is lai

Mundane

Signal recognition particle-depencent protein targeting, universal to all kingdoms of life,nt as bacteria and humans, archaea and plants. The unifying concept of SRP-dependent protein targeting is that SRP binds to signal sequences of newly synthesized proteins as they emerge from the ribosome. In eukaryotes this interaction arrests or retards translation elongation until SRP targets the

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繁殖

Molecular basis of skeletal muscle plasticity-from gene to form and function,), loading conditions (resistance training, microgravity), substrate supply (nutritional interventions) or environmental factors (hypoxia). The presented data show that adaptive structural events occur in both muscle fibres (myofibrils, mitochondria) and associated structures (motoneurons and capill

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