Titlebook: Retroviral Proteases; Control of maturatio Laurence H. Pearl Textbook 1990Latest edition Macmillan Publishers Limited 1990 AIDS.biology.evo

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HIV , Expression via a Ribosomal Frameshift,es is also strongly conserved (Figure 1) (Weiss ., 1982). The . and . genes are adjacent at the beginning of retroviral transcriptional unit and in most cases the 3′ end of . and the 5′ end of . overlap by up to a few hundred nucleotides with . in the ?1 translational phase with respect to .. Both g

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Biosynthesis and Processing of the , and , Polyproteins of Human Immunodeficiency Virus Type 1 in , encodes four group specific antigens, MA(p17), CA(p24), NC(p7) and p6, while the . gene codes for protease, reverse transcriptase/ribonuclease H (RT/RH, 66 kDa) and integrase (IN, 32 kDa) (Chassagne ..., 1986; Henderson ., 1988; Kramer ., 1986; Lightfoot ., 1986; Lillehoj ., 1988). The primary tran

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Three-dimensional Structure and Evolution of HIV-1 Protease, consequence the proteinase is an attractive target for prospective antiviral agents for the treatment of AIDS, and knowledge of its tertiary structure an important step in drug design. Following the observation (Toh . 1985) that retroviral proteinases shared a highly conserved sequence Asp-Thr/Ser-

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Expression of HIV-1 , and , Gene Products using Recombinant Baculoviruses,pression of heterologous gene products. Genes of interest are introduced into the genome of the . nuclear polyhedrosis virus (AcNPV) to give a helper independant recombinant virus that, upon infection of insect cells, produces the product encoded by the introduced gene in a regulated manner. Frequen

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Morphogenesis of Retroviruses: A Complex Role for the Matrix (MA) Protein in Assembly, Stability anne of an infected cell. They have common morphological features that reflect similar mechanisms of morphogenesis. The viral envelope is studded with glycoprotein knobbed-spikes, and in nascent particles surrounds an icosahedral capsid assembled mostly from internal structural proteins encoded by the

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Terminal Stages of Retrovirus Morphogenesis,ical and ultrastructural results of ours and other laboratories, over the past 15–20 years (Luftig and Kilham, 1971; Bolognesi, Luftig and Shaper, 1973; Yoshinaka and Luftig, 1977a,b; Jamjoom, Naso and Arlinghaus, 1976; Yoshinaka ., 1985; Katoh ., 1985; Traktman and Baltimore, 1982; Crawford and Gof