Titlebook: Retinoids; The Biochemical and Heinz Nau,William S. Blaner Book 1999 Springer-Verlag Berlin Heidelberg 1999 Nuclear receptors.Regulation.R

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0171-2004 acologic aspectsIn the future‘ the decade of the 1990s will likely be viewed as a Golden Age for retinoid research. There have been unprecedented research gains in the understanding of retinoid actions and physiology; since the retinoid nuclear receptors were first identified and the importance of r

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Retinoids in Neural Developmentbinding proteins and retinoid receptors and the results of interference with their signalling functions; the detection of endogenous retinoids; and the distribution of retinoid synthesising enzymes. Each of these topics are reviewed below.

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The Retinoids: Cancer Therapy and Prevention Mechanismsusses this convergence through an analysis of retinoid-based cancer therapy and prevention mechanisms. Attention focuses on how an understanding of the retinoid signaling pathway provides insight into mechanisms responsible for retinoid clinical responses.

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The Role of Retinoids in Vertebrate Limb Morphogenesis: Integration of Retinoid- and Cytokine-Mediatcy in vitamin A causes squamous metaplasia and keratinization of most columnar epithelia of the body. Subsequently, . and . (1953) showed that high concentrations of vitamin A suppressed keratinization of epithelia and caused this tissue to differentiate into a mucussecreting, ciliated epithelium.

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Physical-Chemical Properties and Action of Retinoidsameters that govern the behavior of retinoids within aqueous phases, biological membranes, and binding sites of proteins. The possible implications of this information for the molecular mechanisms underlying some aspects of retinoid biology are then considered.

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Retinoic Acid Synthesis and Metabolism of retinal to retinoic acid (. and . 1994). Thus,it has long been understood that retinoic acid synthesis from its precursor retinol involves a two step oxidation that resembles the oxidation of ethanol to acetic acid.

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