Titlebook: Retinal Degenerative Diseases XIX; Mechanisms and Exper John D. Ash,Eric Pierce,Christian Grimm Conference proceedings 2023 The Editor(s) (

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Disturbed Matrix Metalloproteinases Activity in Age-Related Macular Degeneratione components. Because it is associated with development, morphogenesis, tissue remodeling, and repair, ECM remodeling is an important mechanism. MMPs are thought to act as a double-edged sword, as they contribute to maintaining photoreceptors/retinal pigment epithelium (RPE)/Bruch’s membrane (BM)/ch

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Decoding Race and Age-Related Macular Degeneration: GPR 143 Activity Is the Keyvelop AMD than any other race, indicating a racial bias in AMD incidence which is unexplained. We hypothesize that pigmentation of the retinal pigment epithelium (RPE)?and choroid?protects from AMD and underlies this peculiar racial bias. We investigated GPR143, a receptor in the pigmentation pathwa

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Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1Alpha (PGC-1α): A Transcriptional Reguure studies from AMD patients have implicated impaired activity of peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1α). PGC-1α is a transcriptional co-regulator that acts to control a plethora of metabolic processes relevant to AMD pathophysiology including gluconeogenesis,

heterogeneous

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The Role of Gene Expression Regulation on Genetic Risk of Age-Related Macular Degenerationsed by the cumulative impact of genetic predisposition, environmental stress, and advanced aging. Knowledge of genetic risk factors underlying AMD susceptibility has advanced rapidly in the past decade that can be largely credited to genome-wide association studies (GWAS) and next-generation sequenc

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Extracellular Vesicle RNA Contents as Biomarkers for Ocular Diseasesells from which they originate. For this reason, EVs are being studied for use as biomarkers as they can be surrogates for the status of the cell from which they are secreted. Moreover, EVs are found in numerous biofluids and can be taken up by other cells, which allows for transfer of functional ca