Titlebook: Retinal Degenerative Diseases; Mechanisms and Exper Catherine Bowes Rickman,Christian Grimm,Joe G. Hol Conference proceedings 2019 Springer

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A Review of Pathogenic Drivers of Age-Related Macular Degeneration, Beyond Complement, with a?Focus multifactorial, progressive disease with diverse molecular pathways regulating its pathogenesis. One of the cardinal features of the early clinical subtype of AMD is the accumulation of lipid- and protein-rich deposits within Bruch’s membrane, called drusen, which can be visualized by fundus imagin

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Isolation of Retinal Exosome Biomarkers from Blood by?Targeted Immunocapturem the photoreceptors, among many other functions. Because of these critical roles in visual homeostasis, the RPE is a principal location of disease-associated changes in age-related macular degeneration (AMD), emphasizing its importance for study in both visual health and disease. Unfortunately, the

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Systemic Inflammatory Disease and AMD Comorbiditye greatest risk factor of AMD, other risks such as smoking, family history, complement pathway activation, and race exist. Various systemic inflammatory diseases share many of these risk factors with AMD, as well as a similar inflammatory profile. Due to these similarities, patient database studies

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Adaptive and Maladaptive Complement Activation in the?Retinaal functions influential during development and disease. In the retina, local complement expression and activation have been detected in response to injury, and polymorphisms in complement genes have also been linked to the genetic risk for retinal disease. While knowledge regarding the functions, e

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Long-Chain Polyunsaturated Fatty Acids and Age-Related Macular Degeneration (LC and VLC-PUFAs) have been linked to AMD pathogenesis through epidemiologic, biochemical, and genetic studies; however, the exact mechanisms of pathogenesis are unknown. Here, we review the scientific and clinical evidence supporting the role of PUFAs in AMD and discuss future directions for eluc

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Melatonin as the Possible Link Between Age-Related Retinal Degeneration and the Disrupted Circadian ns to believe that impairment in circadian rhythm may affect incidence and pathogenesis of AMD. The current understanding of AMD pathology is based on age-related, cumulative oxidative damage to the retinal pigmented epithelium (RPE) partially due to impaired clearance of phagocytosed photoreceptor

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Active Cholesterol Efflux in the?Retina and Retinal Pigment Epithelium macular degeneration (AMD) prompted in the last years a deep investigation of its metabolism in the retina. Here, we focus on the export of cholesterol from intracellular membranes to extracellular acceptors, an active mechanism mediated by the ATP-binding cassette transporters A1 and G1 (ABCA1 and

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Systematic Injection of Low-Dose LPS Transiently Improves the Retina Function and Structure of a?Mouc . knockout mouse model of GA develops increase oxidative stress and slow retinal degeneration. Mice of the SOD2.::VMD2. genotype were injected subcutaneously with either saline or 3?mg/kg of lipopolysaccharide (LPS) at 8?weeks of age. Mice were evaluated by electroretinography (ERG) and spectral d