Titlebook: Restoration of Brain Function by Tissue Transplantation; Olle Lindvall Conference proceedings 1993 Springer-Verlag Berlin Heidelberg 1993

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Conference proceedings 1993 evidence, however, no treatment basedontransplantation is available yet. An overview of currentresearch is givenin this book. It summarizes the status ofgrafting in humans and discussesscientific problems thathave to be solved before intracerebral transplantation canbecome a useful routine approach to treatment.

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Introduction,other. We did many things to him but it was impossible for us to restore his brain.” Obviously, they did not transplant any brain tissue, or did not do so successfully, but the idea was already there over 400 years ago [3].

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,Transplantation in Huntington’s Disease: Experimental Basis and Clinical Perspectives,ps at 35–45 years of age, show a series of symptoms including severe cognitive and emotional disturbances and incapacitating involuntary movements (chorea). The disease generally progresses over 10–20 years, leading directly or indirectly to death (for comprehensive reviews, see [2] and [12]).

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0941-9772 the status ofgrafting in humans and discussesscientific problems thathave to be solved before intracerebral transplantation canbecome a useful routine approach to treatment.978-3-540-55823-1978-3-642-77718-9Series ISSN 0941-9772

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,Transplantation in Parkinson’s Disease,ually causes motor symptoms, primarily tremor, rigidity, and hypokinesia. Despite the marked symptomatic relief initially provided by .-dopa treatment, there is in most patients with advanced PD a progressive loss of efficacy of the drug, associated with diurnal oscillations in motor performance (“o

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,Transplantation in Huntington’s Disease: Experimental Basis and Clinical Perspectives, to play an as yet undetermined role. Atrophy of the striatum, associated with extensive neuronal loss, is the most constant neuropathologic finding, and the extent of striatal atrophy has been correlated with the progression of the disease [21]. Affected patients, in whom the disease usually develo