Titlebook: Resolving the Antibiotic Paradox; Progress in Understa Barry P. Rosen,Shahriar Mobashery Book 1998 The Editor(s) (if applicable) and The Au

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Antifolate Resistance Mechanisms from Bacteria to Cancer Cells with Emphasis on Parasites,n fungal infections caused by . (Hitchings, 1989). The antifolate methotrexate (MTX) is widely used for the treatment of various forms of cancer as well as for the treatment of rheumatoid arthritis, psoriasis and some autoimmune diseases (Gorlick et al., 1996). The primary structures of DHFR from a

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Peptidoglycan Biosynthesis,every known antibiotic. Very scary are the organisms, like methicillin resistant . (MRSA), that are resistant to everything except vancomycin, and that leave infected patients with few treatment options. Bacteria that were formerly of little threat are now potential killers, because antibiotics that

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0065-2598 se of antibiotics. When it became evident that a number of people were returning for multiple visits to their family physicians for persist- ent ear infections 978-1-4613-7220-2978-1-4615-4897-3Series ISSN 0065-2598 Series E-ISSN 2214-8019

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Marc Ouellette,éric Leblanc,Christoph Kündig,Barbara Papadopoulou

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Rita Mukhopadhyay,Jiaxin Li,Hiranmoy Bhattacharjee,Barry P. Rosen